Corticosteroids have been shown to be teratogenic in many species when given in doses equivalent to the human dose. Animal studies in which corticosteroids have been given to pregnant mice, rats, and rabbits have yielded an increased incidence of cleft palate in the offspring. There are no adequate and well-controlled studies in pregnant women. Corticosteroids should be used furing pregnancy only if the potential benefit justifies the potential risk to the fetus. Infants born to mothers who have received corticosteroids during pregnancy should be carefully observed for signs of hypadrenalism. In a very small number of people with pancreatic cancer, early symptoms might be present that could lead to an earlier diagnosis. Unfortunately, researchers have been unable to identify any predictable pattern.
Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and apply 1 drop in the lower eyelid. Look downward and gently close your for 1 to 2 minutes. Place one finger at the corner of your eye near the nose and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye. Side effects may be more likely when used at higher dosages. Zyrtec may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking Zyrtec for a few days before the tests.
Use air conditioning because it removes excess air moisture, filters out pollens from the outside, and provides air circulation throughout your home. Filters should be changed per the manufacturer's recommendations. If you miss a dose of montelukast, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. As it grows and spreads, pancreatic cancer affects the whole body.
Corticosteroids can product reversible HPA axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal of treatment. Drug induced secondary adrenocortical insufficiency may be minimized by gradual recution of dosage. This type of relative insufficiency may persist for months after discontinuation of therapy; therefore, in any situation of stress occurring during that period, hormone therapy should be reinstituted. Cholestyramine: Cholestyramine may increase the clearance of corticosteroids. Discontinuation of corticosteroids may result in clinical improvement. Use mometasone spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.
In the post-marketing period, the following additional rare, but potentially severe adverse events have been reported: aggressive reaction, anaphylaxis, cholestasis, convulsions, glomerulonephritis, hallucinations, hemolytic anemia, hepatitis, orofacial dyskinesia, severe hypotension, stillbirth, suicidal ideation, suicide and thrombocytopenia. Cardiovascular: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction see WARNINGS pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor right away. You will need to discuss the benefits and risks of using montelukast while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use montelukast, check with your doctor. Discuss any possible risks to your baby. Store at room temperature away from light and moisture. Do not store in the bathroom. Different brands of this medication may have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medications away from children and pets. Novartis Pharmaceuticals Corporation April, 2015. Montelukast may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use montelukast with caution. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Kenalog-40 suspension while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use Kenalog-40 suspension, check with your doctor. Discuss any possible risks to your baby. It may but does not always help to wash the animal at least once a week to remove excess dander and collected pollens. This, together with a decrease in the protein matrix of the bone secondary to an increase in protein catabolism, and reduced sex hormone production, may lead to inhibition of bone growth in pediatric patients and the development of osteoporosis at any age. Pale-colored stools. If the duct draining bile into the intestine is blocked by pancreatic cancer, the stools may lose their brown color and become pale or clay-colored. Urine may become darker. In most parts of the country, the season used to start in mid-August and run through September; now it seems to begin from the first of August through mid-October. Store Flonase in an upright position at room temperature, away from moisture and heat. Throw the spray bottle away after you have used 120 sprays, even if there is still medicine left in the bottle. Persons who are on corticosteroids should be warned to avoid exposure to chicken pox or measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay. Corticosteroids should be used cautiously in patients with ocular herpes simplex because of possible corneal perforation.
Patients with have chronic of their airways. Inflamed airways are "twitchy" and tend to constrict or narrow whenever they are exposed to a trigger such as infection or an allergen. Some children with asthma may have increased in the and airways every day without knowing it. Their breathing may sound normal and wheeze-free when their airways are actually narrowing and becoming inflamed, making them prone to a flare-up. To better assess a child's breathing and determine risk for an or flare-up breathing tests may be helpful. Breathing tests measure the volume and speed of air as it is exhaled from the lungs. make several measurements with a spirometer, a computerized machine that takes detailed measurements of breathing ability. Flea larvae spin a cocoon, and, when appropriately stimulated, a young adult flea emerges and jumps onto your pet to continue the life cycle. When these new fleas are seen on your pet, treat with Capstar Tablets. The most common adverse reaction in patients aged 12 years and older that occurred more frequently on cetirizine than placebo was somnolence. But the symptoms I was getting were not those of anxiety. They included feelings of uncertainty, worry about nothing in particular confusion about my feelings, and general mental malaise. This led to feelings of extreme hopelessness. In addition, they were not at all cyclic; rather, I was getting the symptoms nearly every day. The lowest possible dose of corticosteroid should be used to control the condition under treatment, and when reduction in dosage is possible, the reduction should be gradual. Please read the insert contained in each package for complete information on the individual products prior to dosing. The usual dose of Flonase is 1 to 2 sprays into each nostril once per day. Your dose may change after your symptoms improve. Follow all dosing instructions very carefully. Mometasone spray is used in the nose. coreg
Cmax was decreased by 23% and 37%, respectively in the presence of food. The rarity and vagueness of these situations points out the difficulty of using early symptoms to catch pancreatic cancer at an earlier stage. If your symptoms do not improve or if they become worse, check with your doctor. Immediately following the treatment, use an ice pack to soothe the treated area. To ensure you get proper treatment and care, find a reputable dermatologist or center. If possible, get a recommendation from your primary care physician for a dermatologist or surgery center that specializes in tattoo removal. Literature reports suggest an apparent association between the use of corticosteroids and left ventricular free wall rupture after a recent myocardial infarction; therefore, therapy with corticosteroids should be used with great caution in these patients. Which is more sedating? Selective antihistamines, including cetirizine, may cause drowsiness or dizziness, although it is less likely than with nonselective antihistamines. All second generation antihistamines, including Zyrtec and Claritin, are effective for acute and chronic urticaria, although more trials have been conducted in people with chronic urticaria. No trial has consistently found one antihistamine to be better than another. Seasonal Allergic Rhinitis: Cetirizine is indicated for the relief of symptoms associated with seasonal allergic rhinitis due to allergens such as ragweed, grass and tree pollens in adults and children 2 years of age and older. Symptoms treated effectively include sneezing, rhinorrhea, nasal pruritus, ocular pruritus, tearing, and redness of the eyes. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. When mold or counts are high, give your child recommended by your doctor usually an like or before going outdoors. fibo.info furosemide
Ask a doctor or pharmacist before using any other cold, allergy, or sleep medicine. Antihistamines and decongestants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine or decongestant. There are also self-care and preventative strategies, which can decrease AD symptoms. Avoiding known triggers is foremost, but keeping natural moisture in the skin is an important goal. This can be achieved by decreasing use of drying soaps and prolonged hot baths. Store between 39-77 degrees F 4-25 degrees C away from light and moisture. If you are using the single-dose container, discard it after use. Discard unused single-dose containers 4 weeks after you first open the pack or 3 months after opening if you store them in the original carton box. not store in the bathroom. Keep all medicines away from children and pets. Before using mometasone spray the first time, pump it up to 10 times or until a fine mist appears. Kidney problems often lead to life-threatening conditions that require immediate hospitalization and treatment. If left untreated, end-stage kidney failure will occur, leading to a fatal outcome. Nathanael S. Horne, MD, clinical assistant professor of medicine at New York Medical College in Valhalla and an allergy specialist in private practice in New York City. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using mometasone spray while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use mometasone spray, check with your doctor. Discuss any possible risks to your baby. If the patient is a young child, an adult should help the child use fluticasone furoate spray. Corticosteroids may exacerbate systemic fungal infections and therefore should not be used in the presence of such infections unless they are needed to control drug reactions. There have been cases reported in which concomitant use of amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failure see CONTRAINDICATIONS and PRECAUTIONS, Drug Interactions, Amphotericin B injection and potassium-depleting agents. Montelukast will not stop an asthma attack once one has started. Be sure you always carry appropriate medicine eg, bronchodilator inhalers with you in case of an asthma attack. If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does. If you are exposed, contact your doctor at once. Continue to use this medication for the full time prescribed, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection. Cetirizine is also used to treat itching and swelling caused by chronic urticaria hives. Thin postnasal drip secretions caused by allergies may be treated with antihistamines. Second-generation antihistamines such as Zyrtec and Claritin may offer better relief than older-type antihistamines such as promethazine older antihistamines tend to thicken post-nasal secretions. Focalin dexmethylphenidate hydrochloride US prescribing information.
This information should not be used to decide whether or not to take Zyrtec-D 12 Hour or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Zyrtec-D 12 Hour. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Zyrtec-D 12 Hour. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Zyrtec-D 12 Hour. Ask your doctor or pharmacist about using this product safely. Do not receive a live vaccine eg, measles, mumps while you are using Kenalog-40 suspension. Talk with your doctor before you receive any vaccine. If exposed, to chicken pox, prophylaxis with varicella zoster immune globulin VZIG may be indicated. If exposed to measles, prophylaxis with pooled intramuscular immunoglobulin IG may be indicated. See the respective package inserts for complete VZIG and IG prescribing information. This medication has been prescribed for your current condition only. Do not use it later for another infection unless told to do so by your doctor. A different medication may be necessary in that case. No accumulation was observed. Ophthalmic: Exophthalmos, glaucoma, increased intraocular pressure, posterior subcapsular cataracts, rare instances of blindness associated with periocular injections. An extra patient leaflet is available with fluticasone furoate spray. Talk to your pharmacist if you have questions about this information. authorized generic of grifulvin
Do NOT use more than the recommended dose or use more often than prescribed without checking with your doctor. Some products that may interact with this drug include: lithium, drugs that may increase the level of potassium in the blood such as amiloride, cyclosporine, eplerenone, tacrolimus, triamterene, birth control pills containing drospirenone. In general, symptoms appear earlier from cancers in the head of the pancreas, compared to those in the body and tail. After exposure to an allergen, the immune system releases the chemical histamine into your system. The histamine travels through your and latches onto histamine receptors on other cells. Once attached, the histamine causes the cells to swell. This inflammation causes many familiar allergy symptoms. drugs work by blocking the histamine from affecting these cells. Ask your health care provider if mometasone spray may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Capstar Tablets kill adult fleas and are indicated for the treatment of flea infestations on dogs, puppies, cats and kittens 4 weeks of age and older and 2 pounds of body weight or greater. Corticosteroids may mask some signs of infection, and new infections may appear during their use. Infections with any pathogen including viral, bacterial, fungal, protozoan or helminthic infections, in any location of the body, may be associated with the use of corticosteroids alone or in combination with other immunosuppressive agents that affect cellular immunity, humoral immunity, or neutrophil function. Advair is made by GlaxoSmithKline, a WebMD sponsor. Many can work for anxiety disorders. They include and fluoxetine . Certain anticonvulsant medicines typically taken for and low-dose antipsychotic drugs can be added to help make other treatments work better. Anxiolytics are also drugs that help lower anxiety. Examples are alprazolam and clonazepam Klonopin. What Causes a Ruptured Spleen? You may experience increased blood pressure, rapid heartbeat, seizures, or hallucinations. For the best effect, use this antibiotic at evenly spaced times. To help you remember, use this medication at the same times every day. Allergic states: Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, transfusion reactions. azelastine near logan airport
Other causes of chest pain not due to the heart include problems with the esophagus, gastroesophageal reflux disease GERD musculoskeletal chest wall pain, problems in the lungs, and many others. Desloratadine is to be used only by the patient for whom it is prescribed. Do not share it with other people. Do not use if you have ever had an allergic reaction to this product or any of its ingredients or to an antihistamine containing hydroxyzine. Tell your doctor if you regularly use other medicines that make you sleepy such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety. They can add to sleepiness caused by cetirizine. Bernstein says that environmental control should be a crucial part of treatment. This information should not be used to decide whether or not to take mometasone spray or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about mometasone spray. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to mometasone spray. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using mometasone spray. HPA physiology may be helpful in understanding this rationale. Acting primarily through the hypothalamus a fall in free cortisol stimulates the pituitary gland to produce increasing amounts of corticotropin ACTH while a rise in free cortisol inhibits ACTH secretion. Normally the HPA system is characterized by diurnal circadian rhythm. Serum levels of ACTH rise from a low point about 10 pm to a peak level about 6 am. Increasing levels of ACTH stimulate adrenal cortical activity resulting in a rise in plasma cortisol with maximal levels occurring between 2 am and 8 am. This rise in cortisol dampens ACTH production and in turn adrenal cortical activity. There is a gradual fall in plasma corticoids during the day with lowest levels occurring about midnight. Ask your doctor or before taking any over-the-counter meds or herbal remedies. Many contain chemicals that can make worse.
Visit our website at www. This is why allergy pretreatment is so important. If you miss a dose of Zyrtec-D 12 Hour, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. No one wants to call 911 or sit in an emergency room to be treated for what turns out to be gas pain. However, playing a waiting game when you are having chest pain can be a gamble with your health, or maybe your life. Use Claritin-D exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Middleton B, Bates DW. High-priority drug-drug interactions for use in electronic health records. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using fluticasone furoate spray while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use fluticasone furoate spray, check with your doctor. Discuss any possible risks to your baby. Treat all infested pets in the household. Fleas can reproduce on untreated pets and allow infestations to persist. Windom says. “Choosing the best drug depends a lot on what worked for you in the past. average price of periactin 100mg
Some MEDICINES MAY INTERACT with Kenalog-40 suspension. Qnasl uses the environmentally friendly propellant HFA. Each canister holds 120 sprays, enough for two spritzes in each nostril once daily for 30 days. The canisters have meters showing the remaining number of doses. Fekety R. Infections associated with corticosteroids and immunosuppressive therapy. In: Gorbach SL, Bartlett JG, Blacklow NR, eds. Infectious Diseases. Higher income. Career mobility. My daughter takes a daily antihistamine for IA Idiopathic Anaphylaxis and gradually becomes accustomed to claritin and allegra so we cycled her through Zyrtec. We tried it when she was 12 and it made her hyperactive, unable to sleep and frustrated and I stopped it within a few days. Now she is 18 we tried it again and she has had heart palpitations, stomach ache, sore throat and general malaise within 48 hrs that has not cleared up for 3 weeks. Her allergy symptoms are gone but the side effects are intolerable. She did best on Allegra but we need to find an alternative to cycle her through. I won't use Zyrtec again. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Avoid drinking alcohol. It can increase some of the side effects of cetirizine. Zyrtec one week ago on something of a whim, and starting about 36 hours after I took the last one, I started feeling better. I have felt good every day this week. It occurred to me this morning that the two might be related, so I went back and looked at my records as to when I had started taking the medication and when I had started feeling bad, and noticed the correlation. Of course I can't be sure that Zyrtec was the cause of these symptoms, but as I had never experienced anything like them before, they started soon after I started the medication and stopped soon after I stopped it, I will certainly not be taking Zyrtec again. I'd much rather be sneezing. Shake fluticasone furoate spray well before each use. Burning or irritation inside the nose; coughing; headache; muscle and joint pain; nosebleed or pink color to the mucus; painful menstruation; sinus pain or pressure; sore throat; upper respiratory tract infection; vomiting. Zyrtec is a brand name for the drug cetirizine and Claritin is a brand name for the drug loratadine. Both cetirizine and loratadine are popular with many similarities but there are some important differences. Day JH, Briscoe M, Widlitz MD. Cetirizine, loratadine, or placebo in subjects with seasonal allergic rhinitis: effects after controlled ragweed pollen challenge in an environmental exposure unit. J Allergy Clin Immunol. If you have any questions about Zyrtec-D 12 Hour, please talk with your doctor, pharmacist, or other health care provider. Teva says Qnasl will be available by prescription beginning this April. A price hasn't been announced, but Teva says it will be "competitive. diltiazem
Specialized immune cells start churning out antibodies to proteins in the pollen. The ultimate weapon against ragweed allergy and allergies in general is immunotherapy. In this tried-and-true therapy -- effective in about 85% of allergic rhinitis sufferers -- the patient receives a series of injections of the allergy-causing agent until the body no longer mounts an immune response. FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Approximately 24 hours after ingesting the pill, we experience identical reactions such as a severe full-body itch and hives. I have been weaning myself off the medication due to fears that my reactions will evolve into more extreme symptoms such as thyroid or liver conditions as cited in other Consumer Affairs complaints. It is my 10th day off of Zyrtec and I am still experiencing unrelenting pain. Contact your doctor if you have a sore in your nose or if you have had recent nasal surgery or an injury that has not healed. Use only polyester-filled pillows and comforters never feather or down. Use mite-proof covers available at allergy supply stores over pillows and mattresses. Keep covers clean by vacuuming or wiping them down once a week. This medication passes into milk. Consult your doctor before -feeding. When you follow the first three steps of asthma control, your child will have fewer asthma symptoms and flare-ups. Remember that any child with asthma can still have an occasional asthma attack, particularly during the learning period between diagnosis and control or after exposure to a very strong or new trigger. With proper patient education, having the right medications on hand, and keen observation, families can learn to control most minor asthma flare-ups by starting treatment early, which will mean less emergency room visits and fewer admissions, if any, to the hospital. Many people using this medication not have serious side effects. Simon FER, Simons KJ. H1 Antihistamines: Current Status and Future Directions. The World Allergy Organization Journal.
Fluticasone furoate spray is to be used only by the patient for whom it is prescribed. Do not share it with other people. Do not change your dose or take desloratadine more often than prescribed without checking with your doctor. Drowsiness may occur if you take more of desloratadine than prescribed. Patients who are on corticosteroids are more susceptible to infections than are healthy individuals. There may be decreased resistance of inability to localize infection when corticosteroids are used. Injections with any pathogen viral, bacterial, fungal, protozoan, or helminthic in any location of the body may be associated with the use of corticosteroids alone or in combination with other immunosuppressive agents. You feel excessive, unrealistic worry and tension with little or no reason. You will need to prime fluticasone furoate spray before you use it for the first time. To prime fluticasone furoate spray, shake it well then spray 6 test sprays in to the air away from your face. And there are very few side effects. Eggs hatch and can develop into adults within only three weeks. Store mometasone spray at 77 degrees F 25 degrees C. Brief storage at temperatures between 59 and 86 degrees F 15 and 30 degrees C is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep mometasone spray out of the reach of children and away from pets. pyrantel
Choose from Top Nursing Uniform Companies. All sizes, styles and popular name brands available. Drugs which induce cytochrome P450 34A enzyme activity may enhance the metabolism of corticosteroids and require that the dosage of the corticosteroid be increased. There have been cases reported in which concomitant use of amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failure. Similarly, pediatric patients aged 6 to 11 years with impaired renal or hepatic function should use the lower recommended dose. This may not be a complete list of all interactions that may occur. Ask your health care provider if desloratadine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Take desloratadine by mouth with or without food. Tell your doctor right away if you have see Side Effects section. Gastrinomas excess : abdominal pain, nonhealing ulcers, reflux, weight loss. Initially, pancreatic tends to be silent and painless as it grows. Dermatologic: Acne, allergic dermatitis, burning or tingling especially in the perineal area after intravenous injection cutaneous and subcutaneous atrophy, dry scaly skin, ecchymoses and petechiae, edema, erythema, hyperpigmentation, hypopigmentation, impaired would dealing, increased sweating, rash, sterile abscess, striae, suppressed reactions to skin tests, thin fragile skin, thinning scalp hair, urticarial. This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Continued What Is Allergy Pretreatment?
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Intramuscular corticosteroid preparations are contraindicated for idiopathic thrombocytopenic purpura. One may also have a yellow- or blood-tinged nipple discharge from the affected side. In later stages there can be an ulcer or mass in the areola. Most often, PD involves only one breast. Thus it is not usually linked to bilateral nipple itching or rashes. Clean the inside of the cap once a week with a clean, dry tissue. Never try to clean the nozzle with a pin or anything sharp; doing so may damage the nozzle.
ZYRTEC C5" on one side. They should not use the drug if they have or any untreated infection. Corticosteroids should not be used in cerebral malaria. There is currently no evidence of benefit from steroids in this condition. If you have any questions about desloratadine, please talk with your doctor, pharmacist, or other health care provider. There is an enhanced effect due to decreased metabolism of corticosteroids in patients with cirrhosis.
For lots of people, is reactive. You get stuffed up, your water, and then you go to the medicine cabinet for relief. In these cases, other tests may be used to help diagnose a spleen rupture. People with pancreatic cancer sometimes report itching all over. Blockage of the bile ducts is often responsible.
In other indications, initial dosage will vary from 10 to 40 mg of methylprednisolone depending on the specific disease entity being treated. However, in certain overwhelming, acute, life-threatening situations, administrations in dosages exceeding the usual dosages may be justified and may be in multiples of the oral dosages. It Should Be Emphasized that Dosage Requirements are Variable and Must Be Individualized on the Basis of the Disease Under Treatment and the Response of the Patient. After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reached.